Reducing Health Inequalities Is a Matter of Swimming against the Current

Reducing health inequalities is very much a matter of “swimming against the current”, says Professor Johan Mackenbach, Chair of the scientific committee of the ALLEA-FEAM report Health Inequalities Research: New Methods, Better Insights? “When societies become more unequal, as they do in many European countries, it is very hard to stop the health consequences of these inequalities from widening”, he explains in this interview with the ALLEA Digital Salon.

As one of the leading experts in public health in Europe, Mackenbach has dedicated a career to understanding the underlying causes of what makes some sicker than others. He has (co-)authored more than 700 papers in international, peer-reviewed scientific journals, as well as a number of books, and is a former editor-in-chief of the European Journal of Public Health. Over the course of his prolific career, he has come to recognise that there are no quick fixes to close the health inequalities gap, but points out that with more advanced research methods now available to understand causal mechanisms, perhaps more effective policy interventions can be developed.

“Only a few countries in Europe have taken serious action to translate scientific insights into policies and interventions to reduce health inequalities.”

Question: In the presentation of the report Health Inequalities Research: New Methods, Better Insights?, you said that health inequalities have no clear tendency to decline, and persist in even the most advanced welfare states.  What are some first steps that we can take to narrow this gap?

Johan Mackenbach: It is indeed disappointing that, despite the growth of scientific knowledge on health inequalities, European countries have not been successful in narrowing the gap in morbidity and mortality between socioeconomically disadvantaged people and their richer or better educated counterparts. This is partly due to lack of effort: unfortunately, only a few countries have taken serious action to translate scientific insights into policies and interventions to reduce health inequalities. However, it is also partly due to the fact that trying to reduce health inequalities is very much a matter of “swimming against the current”: when societies become more unequal, as they do in many European countries, it is very hard to stop the health consequences of these inequalities from widening. While this shows that there is no “quick fix”, a lot can be done to reduce health inequalities. Let me give a few examples: Improve working conditions for people in physically or mentally hazardous jobs. Tackle socio-economic inequalities in smoking by raising the price of cigarettes and by offering free smoking cessation support to disadvantaged smokers. Alleviate poverty, particularly among children. Remove barriers to health care, including primary and preventive health care services, in disadvantaged areas.

“In many European countries, smoking is number 1 among the many factors contributing to health inequalities.”

Q.: The study underlines that there is reasonably strong evidence for a causal effect of the number of years of education on mortality in mid-life. Could you elaborate on why this causal effect happens?

J.M.: This is probably due to a cumulation of various beneficial effects of longer, or more, education. Education in large part determines people’s occupational opportunities, and thereby people’s living conditions throughout life. Education also helps people deal with complex problems, such as coping with financial stress or choosing a balanced diet. In addition to these indirect effects, there is also the more direct effect of education on people’s “health literacy”, which is important for understanding health risks and finding your way in the health system. More highly educated people also tend to marry a highly educated partner, which acts as a flywheel for all these beneficial effects.

“If smoking would not be more prevalent among the low educated than among the high educated, inequalities in life expectancy would be reduced by a quarter to a third.”

Q.: What is it not widely known about the causes of health inequalities that we should make people more aware of?

J.M.: In many European countries, smoking is number 1 among the many factors contributing to health inequalities. If smoking would not be more prevalent among the low educated than among the high educated, inequalities in life expectancy would be reduced by a quarter to a third, particularly in North-western Europe where smoking has become highly concentrated in socioeconomically disadvantaged groups. However, what people need to be made more aware of is not this simple fact, but the brutal reality underlying these numbers. The reality of going to school in a poor neighbourhood, where social norms are often pro-smoking and where the likelihood of starting smoking at a young age and thereby getting addicted to nicotine, is much higher. The reality of living in socioeconomic disadvantage makes smoking cessation as an adult much more difficult. And the brutal reality of a tobacco industry which continues to sell its deadly products to people who already have a lower expectancy and deserve to be better protected. If you do not understand these underlying factors, you could be misled to think that health inequalities are mainly a matter of individual responsibility.

“New methods can take advantage of “natural experiments” in which socioeconomic conditions change as a result of non-health-related changes in legislation.”

Q.: The ALLEA-FEAM report provides a review of a new generation of quantitative methods and assesses their contributions in comparison with “conventional” methods. What are the most important takeaways of this evaluation?

J.M.: These new methods can help us answer a number of unanswered questions on the explanation of health inequalities. Scientists are pretty sure that smoking causes lung cancer and other health problems, but they are less certain about causality in the case of education and income versus health, because conventional research methods are more suitable for investigating the health effects of easily identifiable factors like smoking, than for investigating the health effects of socioeconomic conditions. These new methods can help to fill some of these gaps in knowledge, for example by taking advantage of “natural experiments” in which socioeconomic conditions change as a result of non-health-related changes in legislation. This is nicely illustrated by studies looking at the long-term mortality experience of people going to school before and after a change in legislation, which increased compulsory school leaving age by one year. Those who, in this “natural experiment”, went to school longer, simply because they were born later, turned out to live longer as well.

“While there can be no doubt that people living in poverty on average live shorter lives, and suffer from more illnesses during their lives, it is less clear whether this reflects a causal effect of low income on health, or perhaps has other explanations, such as differences in cognitive ability or personality characteristics.”

Q.: As these new methods are being applied, to what extent are they contradicting or shedding light on previous findings regarding the causes of heath inequalities? Could you give an example?

J.M.: An important “contradictory” finding relates to the health effects of low income. While there can be no doubt that people living in poverty on average live shorter lives, and suffer from more illnesses during their lives, it is less clear whether this reflects a causal effect of low income on health, or perhaps has other explanations, such as differences in cognitive ability or personality characteristics. Ideally, one would like to study this by conducting a true experiment in which people are randomized into groups with a higher and a lower monthly income. However, this is only rarely feasible, and these new methods now help scientists take advantage of “natural experiments” in which people receive a higher or lower income as a result of, e.g., a sudden change in welfare benefits or winning a prize in a lottery. Results from these studies have found some evidence for a causal effect of higher or lower income on children’s health and on mental health in adulthood, but surprisingly little evidence for a causal effect of higher or lower income on physical health in adulthood. Because of its policy relevance, this is clearly an area for further research.

“It is essential to include an inequalities perspective in climate change mitigation and adaptation policies, and to make sure that these policies duly protect those who need it most.”

Q.: In your book A History of Population Health: Rise and Fall of Disease in Europe, you argue that the rise of so many diseases indicates that their ultimate cause is not to be sought within the body, but in the interaction between humans and their environment. What does the increasing degradation of the environment and the worsening climate crisis mean for the emergence of new diseases?

J.M.: I am very concerned about the effect of climate change, biodiversity loss, wide-spread chemical pollution and other environmental changes on human health. New health problems are emerging on the horizon before we have solved the problems of the past, such as the tobacco epidemic or, indeed, health inequalities. Unfortunately, health inequalities are likely to become even wider in the future if we do not take effective countermeasures. Climate change is already affecting the health of people in many low-income countries, and when serious effects of climate change reach high-income countries, they will certainly also affect disadvantaged groups more than the rich and high educated. It is therefore essential to include an inequalities perspective in climate change mitigation and adaptation policies, and to make sure that these policies duly protect those who need it most.

About Johan Mackenbach

Johan Mackenbach is Professor Emeritus of Public Health and former chair of the Department of Public Health at Erasmus MC, University Medical Center Rotterdam, the Netherlands. His research interests are in social epidemiology, medical demography, and health policy. He has (co-)authored more than 700 papers in international, peer-reviewed scientific journals, as well as a number of books, including Health inequalities: persistence and change in European welfare states (Oxford University Press, 2019). He is a former editor-in-chief of the European Journal of Public Health, and has been actively engaged in exchanges between research and policy, among others as a member of the Health Council of the Netherlands and the Council for Public Health and Health Care. He is also a member of the Royal Netherlands Academy of Arts and Sciences and the Academia Europaea.

Registration for the Symposium ‘Transforming Science’ Is Now Open

We are pleased to announce that the registration for the symposium ‘Transforming Science: Pathways Towards Sustainability and Trustworthiness’ is now open. The event will take place in Brussels and online on 11-12 May 2022. Scientists, policymakers and professionals from across Europe will join to discuss current trends pressing science in light of the transformations occurred during the Covid-19 pandemic.

The symposium is part of the ALLEA General Assembly and hosted by ALLEA’s Member Academies, the Royal Academy of Sciences, Letters and Arts of Belgium and the Royal Flemish Academy of Belgium for Science and the Arts. Speakers include Mariya Gabriel, European Commissioner for Innovation, Research, Culture, Education and Youth, Marion Koopmans, Director of the WHO Collaborating Centre for Emerging Infectious Diseases at Erasmus MC, and Maria Leptin, President of the European Research Council, among others.

The event will explore how scientific institutions can transform research cultures, trust-building strategies and science advice mechanisms. The consequences of this transformation can be seen as two-sided: from an inspiration to tackle complex global emergencies such as climate change or future pandemics, to a rise of societal expectations and demands towards research. The symposium will tackle the central question: Are we ready to transform science for the future?

The full programme and further details can be found on our symposium website. The symposium is expected to be held in person. The organisers will fully implement the official Covid-19 measures and follow current best practices for public events and international travel. The symposium will also be livestreamed for those who wish to participate digitally. Register now to not miss your spot!

About the ALLEA General Assembly

The General Assembly annually convenes academies of sciences and humanities from 40 countries across the Council of Europe region. General Assemblies are hosted by ALLEA Member Academies and the programme typically consists of the internal business meeting of academy delegates, and a scientific symposium open to the public.

The symposium explores pressing topics from the fields of science, society and policy, and provides a platform for international, interdisciplinary and cross-sectoral debate.

The business meeting addresses governance, strategy and policy matters and is restricted to Member Academies’ delegates.

 

Call for Early/Mid-Career Researchers: European Crucible 2022

The European Crucible is a leadership and development programme for early/mid-career researchers from Scotland and Europe. The call for applications to participate in the 2022 European Crucible is now open to applicants from European institutions until 21st February 2022.

The European Crucible was established to stimulate new international opportunities for early/mid-career researchers. Developed from the national ‘Scottish Crucible’ programme and working with the Scottish Research Pools, European Crucible seeks to establish new networks for aspiring research leaders, and to facilitate international collaborations for interdisciplinary research initiatives and innovations.

Who should apply

The call is open to early/mid-career researchers employed in Scotland or Europe, and carrying out research in science, engineering, technology, medicine, healthcare, arts, design, humanities, business, or social and political science. Ambitious university lecturers and readers (i.e. assistant and associate professors), research fellows and equivalents in research institutes and industry with experience of managing their own research, are encouraged to apply.

How it works 

The Crucible is an intensive, interactive, programme comprising four virtual workshops, or ‘labs’, held over three weeks. The labs will be facilitated by experienced science journalists, Vivienne Parry and Quentin Cooper, and will include contributions from a range of experts from research-related sectors. Crucible participants will be asked to present a mini-poster of their research areas and interests, and there will be networking sessions and pitching practice before a mock panel of real funding experts.

The 2022 European Crucible is a virtual programme supported by the Scottish Government via the Scottish Funding Council. Once awarded a place on the European Crucible Event, all training, networking and administration costs for participants will be covered.

For more information on how to apply, please refer to the programme’s website.

Breakthrough Prize Opens Public Nominations for 2023

The public nomination period for the 2023 Breakthrough Prizes in Fundamental Physics, Life Sciences and Mathematics is now open. Nominations can be submitted online today through April 1, 2022. While self-nominations are prohibited, anyone may nominate another person. The nomination forms and rules are available at breakthroughprize.org.

For the 11th year, the Breakthrough Prize, recognized as the world’s largest science prize, will honor top scientists, handing out three prizes in Life Sciences, one in Fundamental Physics and one in Mathematics. Each prize comes with a $3 million award. In addition, six New Horizons Prizes, each for $100,000, will be available to promising early-career researchers in the fields of Physics and Mathematics. Nominations will also be taken for the Maryam Mirzakhani New Frontiers Prize, an annual $50,000 award presented to early-career women mathematicians who have completed their PhDs within the previous two years.

The Breakthrough Prize, dubbed ‘The Oscars of Science,’ hosts an annual live, globally televised gala awards ceremony to celebrate the laureates’ achievements and to foster broad popular support for scientific endeavors and inspire the next generation of scientists. Due to the pandemic, the ceremonies to honor the 2021 and 2022 laureates were postponed. The next ceremony is scheduled for late 2022. The cohort of 2022 laureates was announced in September 2021.

For the sixth year, the Breakthrough Prize will partner with two prestigious institutions – the European Federation of Academies of Sciences and Humanities (ALLEA) and ResearchGate – to directly engage with researchers and the science community.

ALLEA brings together more than 50 academies from over 40 countries, with members leading scholarly enquiry across all fields of the natural sciences, social sciences, and humanities.

ResearchGate is the professional network for researchers. Over 20 million researchers use researchgate.net to share and discover research, build their networks, and advance their careers. Based in Berlin, ResearchGate was founded in 2008. Its mission is to connect the world of science and make research open to all. ResearchGate members are encouraged to nominate their peers for the 2023 prizes in Fundamental Physics, Life Sciences, and Mathematics.

Selection Committees are composed of previous Breakthrough Prize laureates, who select the winners from the list of candidates generated during the nomination period.

 

New Chair of Breakthrough Prize in Life Sciences

Meanwhile, after eight years of exceptional leadership, Cori Bargmann is stepping down as Chair of the Breakthrough Prize in Life Sciences. One of the inaugural winners of the Prize in 2013, Bargmann has played a pivotal role in its establishment and development. She is succeeded by Huda Yahya Zoghbi, winner of the Prize in 2017 and Founding Director of the Jan and Dan Duncan Neurological Research Institute in Houston.

 

Breakthrough Prize in Fundamental Physics

One 2023 Breakthrough Prize in Fundamental Physics ($3 million) will recognize an individual or individuals who have made profound contributions to human knowledge. It is open to all physicists – theoretical and experimental – working on the deepest mysteries of the Universe. The prize can be shared among any number of scientists. Nominations are also open for the New Horizons in Physics Prize, which will include up to three $100,000 awards for early-career researchers who have already produced important work in their fields.

The Selection Committee for the 2023 physics prizes includes: Eric Adelberger, Nima Arkani-Hamed, Jocelyn Bell Burnell, Charles Bennett, Sheperd Doeleman, Michael Green, Jens Gundlach, Alan Guth, Blayne Heckel, Joseph Incandela, Charles Kane, Hidetoshi Katori, Alexei Kitaev, Andrei Linde, Arthur McDonald, Juan Maldacena, Eugene Mele, Lyman Page, Saul Perlmutter, Alexander Polyakov, Adam Riess, John Schwarz, Nathan Seiberg, Ashoke Sen, Eva Silverstein, David Spergel, Andrew Strominger, Kip Thorne, Cumrun Vafa, Ewine F. van Dishoeck, Yifang Wang, Rainer Weiss, Edward Witten, and Jun Ye.

 

Breakthrough Prize in Life Sciences

Three 2023 Breakthrough Prizes in Life Sciences ($3 million each) will be awarded to individuals who have made transformative advances in understanding living systems and extending human life. One of the prizes is designated for work contributing to the understanding of Parkinson’s disease or other neurodegenerative disorders.

The Selection Committee for the 2023 Breakthrough Prize in Life Sciences includes: David Allis, James Allison, Victor Ambros, David Baker, Shankar Balasubramanian, Cornelia I. Bargmann, Alim Louis Benabid, Frank Bennett, David Botstein, Edward Boyden, Lewis Cantley, Emmanuelle Charpentier, Zhijian “James” Chen, Joanne Chory, Don Cleveland, Hans Clevers, Karl Deisseroth, Titia de Lange, Mahlon DeLong, Jennifer Doudna, Catherine Dulac, Stephen Elledge, Napoleone Ferrara, Jeffrey Friedman, Michael Hall, John Hardy, Ulrich Hartl, Helen Hobbs, Arthur Horwich, David Julius, Katalin Karikó, Jeffery W. Kelly, David Klenerman, Adrian Krainer, Eric Lander, Robert Langer, Virginia Lee, Richard Lifton, Dennis Lo, Pascal Mayer, Kazutoshi Mori, Kim Nasmyth, Harry Noller, Roeland Nusse, Yoshinori Ohsumi, Svante Pääbo, Gary Ruvkun, Charles Sawyers, Alexander Varshavsky, Bert Vogelstein, Peter Walter, Robert Weinberg, Drew Weissman, Shinya Yamanaka, Richard Youle, Xiaowei Zhuang, and Huda Zoghbi.

 

Breakthrough Prize in Mathematics

One 2023 Breakthrough Prize in Mathematics ($3 million) will be awarded to an individual who has made outstanding contributions to the field of mathematics. Nominations are also open for the New Horizons in Mathematics Prize, which will include up to three $100,000 awards for early-career researchers who have already produced important work in their fields. In addition, up to three $50,000 Maryam Mirzakhani New Frontiers Prizes will be presented to early-career women mathematicians who have completed their PhDs within the previous two years (2019, 2020).

The Selection Committee for the 2023 mathematics prizes includes: Ian Agol, Alex Eskin, Simon Donaldson, Martin Hairer, Maxim Kontsevich, Christopher Hacon, Vincent Lafforgue, Jacob Lurie, James McKernan, Takuro Mochizuki, Terence Tao, and Richard Taylor.

Information on the Breakthrough Prizes is available at breakthroughprize.org.